What is Neurotrophic Keratitis: Causes, Symptoms, Treatment

by Feb 9, 2024

Neurotrophic keratitis is a rare but potentially serious eye condition characterized by damage to the cornea due to decreased or complete loss of corneal sensation. This reduced sensitivity prevents normal blinking and tear production, leading to corneal thinning, ulceration, and impaired healing. In this blog, we will explore the common causes, symptoms, and treatment options for neurotrophic keratitis.


Common Causes

Neurotrophic keratitis is typically caused by damage to the trigeminal nerve, which provides sensory innervation to the cornea. Some of the most common causes include:

Herpes Simplex Virus: Prior infection with the herpes simplex virus can damage the trigeminal nerve, leading to neurotrophic keratitis.

Diabetes Mellitus: Diabetic neuropathy can affect the trigeminal nerve and contribute to corneal hypoesthesia, a reduced sensation of the cornea.

Trauma: Any injury or surgical intervention affecting the trigeminal nerve or cornea can result in neurotrophic keratitis.

Neurological Conditions: Neurological disorders such as stroke, multiple sclerosis, or Bell’s palsy can lead to trigeminal nerve damage, causing neurotrophic keratitis.

It’s important to note that not everyone with these risk factors will develop neurotrophic keratitis. Individual susceptibility and severity vary and neurotrophic keratitis is a rare and severe outcome for all of these conditions.


Signs and Symptoms of Neurotrophic Keratitis

The symptoms of neurotrophic keratitis can vary depending on the stage and severity of the condition. Common symptoms include:

 Decreased Corneal Sensation: Individuals may report a lack of sensation in the affected eye.

Eye Dryness: Reduced tear production due to impaired corneal sensation can lead to dry eyes.

Corneal Ulcers: Neurotrophic keratitis can cause non-healing corneal ulcers, which can lead to vision loss if left untreated.

Corneal Infiltrates: Inflammation and infiltration of immune cells in the cornea may be present.

Vision Disturbances: Blurred vision or changes in vision may occur as the condition progresses.

If you experience any of these symptoms, it is crucial to consult with an eye care professional for a comprehensive evaluation.


How Can We Treat Neurotrophic Keratitis?

Early diagnosis and appropriate management are crucial in preventing vision loss and promoting corneal healing in neurotrophic keratitis. Treatment options may include:

Preservation of the Corneal Environment: Lubricating eye drops and ointments can help keep the cornea moisturized, reducing the risk of corneal injury and promoting healing.

Protection and Support: Specialized contact lenses, such as bandage contact lenses, can provide protection to the cornea and enhance its healing.

Medications: In certain cases, your eye care professional may prescribe medications, such as corticosteroid eye drops or autologous serum drops, to reduce inflammation and promote corneal healing.

Surgical Interventions: In severe cases, surgical interventions, such as amniotic membrane transplantation or corneal tissue grafts, may be considered to aid in corneal healing.

Management of Underlying Causes: Addressing and managing any underlying conditions, such as herpes simplex infection or diabetes, is essential to prevent further nerve damage and promote corneal health.

It’s important to work closely with your eye care professional to determine the most suitable treatment plan based on the severity of your condition and individual needs.


Our eye doctors at EyeDocs Family Eye Care in Brookville, OH excel in the prescription of glasses, contact lenses and the diagnosis of a variety of eye diseases. Call our optometrists at 937-770-1265 or schedule an eye exam appointment online if you would like to learn more about neurotrophic keratitis treatment options. Our eye doctors, Dr. Kyle Maxam and Dr. Cara Wampler, provide the highest quality optometry services and eye exams in Brookville, Ohio.

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